近期发表主要论著

近期发表主要论著：

1.   Yong Zhu, Hui-Fang Li, Shuai Lu, Yi-Xuan Zheng, Zeng Wu, Wei-Fang Tang, Xiang Zhou, Tao Lu*. Investigation on the isoform selectivity of histone deacetylase inhibitors using chemical feature based pharmacophore and docking approaches. Eur.

2.  Huifang Li, Yadong Chen, Shasha Rao, Xiumei Chen, Haichun Liu, Weifang Tang, Yue Wang, Xiang Zhou, Tao Lu^*. Recent Advances in the Research and Development of B-Raf Inhibitors. Curr. Med. Chem. 2010, 17, 1618-1634 

3.  Ding Du,*, Yingyan Lu, Jianlin Jin, Weifang Tang, Tao Lu,* N-Heterocyclic carbene-catalyzed hydroacylation of isatins with aldehydes: access to 3-acyloxy-1,3-dihydro-2H-indol-2-ones. Tetrahedron 2011, 67, 7557-7562

4.  Guo-Wu Lin, Yue Wang, Qiao-Mei Jin, Tao-Tao Yang, Jie-Mei Song, Yi Lu, Qing-Jie Huang, Ke Song, Jun Zhou, Tao Lu*, Synthesis, structures and the biological activity study on the metal complexes of 2-(4-aminophenyl) benzothiazole derivative. Inorganica Chimica Acta 2012, 382, 35-42

5.  Du Ding*, Hu Zhongyuan, Jin Jianlin, Lu Yingyan, Tang Weifang, Wang Bo, Lu Tao*. N-Heterocyclic Carbene-Catalyzed Three-Component Domino Reaction of Alkynyl Aldehydes with Oxindoles. Organic Letters 2012, 14(5), 1274-1277

6.  Yue Wang, Qiaomei Jin, Guowu Lin, Taotao Yang, Zhanwei Wang, Yi Lu, Yimin Tang, Lifang Liu, Tao Lu*, Synthesis and Structure of the β-Carboline Derivatives and Their Binding Intensity with Cyclin-Dependent Kinase 2. Chem. Pharm. Bull. 2012, 60(4), 435–441

7.  Qingfa Zhou*, Xueping Chu, Weifang Tang, Tao Lu*, An efficient one-pot synthesis of 1,4-disubstituted 3-amino-2-pyridone derivatives via three-component reactions of alkynyl aldehydes and amines with ethyl 2-((diphenylmethylene)amino)acetate. Tetrahedron 68 (2012) 4152-4158

8.  Botao Xin, Weifang Tang, Yue Wang, Guowu Lin, Haichun Liu, Yu Jiao, Yong Zhu, Haoliang Yuan, Yadong Chen*, Tao Lu*, Design, synthesis and biological evalution of β-carboline derivatives as novel inhibitors targeting B-Raf kinase. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4783–4786

9.  Wenhai Li*, Yue Wang, Tao Lu*, Facile synthesis of 1-aminoisoquinolines via the tandem reactions of 2-alkynylbenzaldoximes with isothiocyanates. Tetrahedron 68 (2012) 6843-6848

10.  Yanmin Zhang, Haichun Liu, Yu Jiao, Haoliang Yuan, Fengxiao Wang, Shuai Lu, Sihui Yao, Zhipeng Ke, Wenting Tai, Yulei Jiang, Yadong Chen*, Tao Lu*, De novo design of N-(pyridin-4-ylmethyl)aniline derivatives as KDR inhibitors: 3D-QSAR, molecular fragment replacement, protein-ligand interaction fingerprint, and ADMET prediction. Mol Divers 2012, 16:787–802

11.  Yingyan Lu, Weifang Tang, Yu Zhang, Ding Du* and Tao Lu*, N-Heterocyclic Carbene-Catalyzed Annulations of Enals and Ynals with Indolin-3-ones: Synthesis of 3,4-Dihydropyrano[3,2-b]indol-2-ones. Adv. Synth. Catal. 2013, 355, 321 – 326

12.  Chen Wang, De-Kai Ye, Yun-Yi Wang, Tao Lu* and Xing-Hua Xia*, Insights into the ‘‘free state’’ enzyme reaction kinetics in nanoconfinement. Lab on a Chip 2013, 13, 1546–1553

13.  Fang-Rong Yan*, Yuan Huang, Jun-Lin Liu, Tao Lu*, Jin-Guan Lin*, Bayesian Inference for Generalized Linear Mixed Model Based on the Multivariate t Distribution in Population Pharmacokinetic Study. PLOS ONE 2013, 8(3) e58369

14.  Qing-Fa Zhou*, Xue-Ping Chu, Fei-Fei Ge, Cheng Li, Tao Lu*, Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions. Mol. Divers. 2013, 17:563–571

15. Qing-Fa Zhou*, Xue-Ping Chu, Fei-Fei Ge, Yue Wang, and Tao Lu*, Phosphine-Catalyzed [3+2] Annulation of Electron-Deficient Alkynes with N-Hydroxyphthalimide: Synthesis of 3a-Hydroxyisoxazolo[3,2-a]isoindol-8 (3aH)-ones. Adv. Synth. Catal. 2013, 355, 2787-2792 

16.  Haoliang Yuan, Wenting Tai, Shihe Hu, Haichun Liu, Yanmin Zhang, Sihui Yao, Ting Ran, Shuai Lu, Zhipeng Ke, Xiao Xiong, Jinxing Xu, Yadong Chen* and Tao Lu*. Fragment-based Strategy for Structural Optimization in Combination with 3D-QSAR. J Comput Aided Mol Des. 2013, 27:897-915 

17.  Yuxi Tao, Junlin Liu, Zhihui Li, Jinguan Lin, Tao Lu*, Fangrong Yan*. Dose-Finding Based on Bivariate Efficacy-Toxicity Outcome Using Archimedean Copula. PLOS ONE 2013, 8(11) e78805,1-6

18.  Yanmin Zhang, Shangyan Yang, Yu Jiao, Haichun Liu, Haoliang Yuan, Shuai Lu, Ting Ran, Sihui Yao, Zhipeng Ke, Jinxing Xu, Xiao Xiong, Yadong Chen,* and Tao Lu*. An Integrated Virtual Screening Approach for VEGFR‑2 Inhibitors. J. Chem. Inf. Model. 2013, 53, 3163−3177  

19.  Sihui Yao, Tao Lu, Zifan Zhou, Haichun Liu, Haoliang Yuan, Ting Ran, Shuai Lu, Yanmin Zhang, Zhipeng Ke, Jinxing Xu, Xiao Xiong, Yadong Chen*. An efficient multistep ligand-based virtual screening approach for GPR40 agonists. Mol. Divers. 2014, 18, 183–193

20.  Qiao-Mei Jin, Yi Lu, Jian-Lin Jin, Hao Guo, Guo-Wu Lin, Yue Wang*, Tao Lu*. Synthesis, characterization, DNA binding ability and cytotoxicity of the novel platinum(II), copper(II), cobalt(II) and nickel(II) complexes with 3-(1H-benzo[d]imidazol-2-yl)-b-carboline. Inorganica Chimica Acta 2014, 421, 91–99